LIF- and IL-6-Induced Acetylation of STAT3 at Lys-685 through PI3K/Akt Activation
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چکیده
منابع مشابه
LIF- and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation.
Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors via specific tyrosine or serine phosphorylation, dimerization and nuclear translocation. A recent study has demonstrated, by using antibody to acetylated lysine, and a STAT3 mutant with Lys-685-to-Arg substitution, that STAT3...
متن کاملBiol. Pharm. Bull. 30(10) 1860—1864 (2007)
is a member of the STAT protein family, and is mainly activated by the interleukin (IL)-6 family of cytokines, interferons, epidermal growth factor and leptin. Similar to other members of the STAT family, upon cytokine stimulation, STAT3 is tyrosine-phosphorylated at Tyr-705 by Janus kinases (Jaks), and is subsequently dimerized and translocated to the nucleus to activate its target genes. STAT...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2007
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.30.1860